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   Garcinia cambogia
 
Botanical Name : Garcinia cambogia
Common Name : Vilayati Imli
Standardized For : Calcium salts upto 70% Hydroxycitric acid (HCA)
                               Potassium salts (water soluble) upto 50% HCA
                               Combined Ca/K Salts (water soluble) upto 60% HCA
                               Magnesium salt (water soluble) upto 60% HCA
Description : Hydroxycitric acid in the form of fine powder
Plant part used : Fruit rind
Applications: Weight Management
 
Introduction:
Garcinia has garnered a lot of attention of late as a popular natural weight loss aid. The reason is that the rind of this pumpkin like fruit is rich in a substance called hydroxycitric acid / HCA, a principle extract of Garcinia cambogia. It is used as an appetite suppressant and to inhibit the absorption and synthesis of fat, cholesterol and triglycerides. In other words, it is a dietary aid
Benefits & Uses:
1. Garcinia has also been considered to make foods more filling and satisfying.
2. Garcinia cambogia was able to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent.
  Mechanism :
This supplement reduced both the volume and acidity of gastric juice. Beside this effect on acid, the supplement showed promotion of defensive factors on gastric mucosa. Garcinia cambogia extract is found to increase the mucosal defensive mechanisms in stomach and thereby it is helpful as a protective agent against Gastric ulcers.
 
  3. Garcinia does not contain any addictive components and can be taken without fear of addiction for extended periods of time.
4. Garcinia also contains significant amounts of Vitamin C and has been used as a heart tonic.
5. Garcinia, when taken over a period of time, has the ability to slow production of fat and help the body metabolize it more efficiently.
6. This species was prescribed for edema, constipation and intestinal parasites.
7. Delayed menstruation or amenorrhea - Women having severely low levels of body fat, enters a state of “negative energy balance” that adversely affects reproductive function and metabolism according. Women stop menstruating and develop hypothalamic amenorrhea, their ovaries cease to function, and their levels of estrogen and other reproductive hormones drop dramatically. Amenorrhea (absence of menstruation) is also associated with a number of other conditions including abnormal thyroid hormone levels, abnormal growth factor levels, and loss of bone mass. Loss of bone mass can lead to osteoporosis and broken bones.
8. Extract from this species is a common ingredient in various herbal appetite suppressant and energy products.
   
 
Garcinia cambogia For Weight Loss:
• Garcinia extract inhibits the accumulation of lipids in fat cells in adipose tissue (Fat droplet size reduced from 30-40 microns to 10-20 microns).

The 60% HCA containing extract of Garcinia cambogia was found to promote fat oxidation enhance serotonin release and its availability in brain, normalization of lipid profiles.

Another study found Garcinia extract to be a potent inhibitor of ATP Citrate lyase, the cellular enzyme that hastens the break of citrate to Acetyl coenzyme A and oxalocitrate. This inhibition of the enzyme reduces the availability of Acetyl coenzyme A for fatty acid and lipid synthesis from spare carbohydrates like starches and sugars. This helps directly in restricting the weight gain. HCA works best when we are taking a normal fat diet and not starving ourselves with greatly reduced fat intake.
   
  HCA works best when we are taking a normal fat diet and not starving ourselves with greatly reduced fat intake.
   
  Mechanism :
 
    • Its action is mediated by two pathways. HCA works by blocking lipogenesis or conversion of starches and sugars (Excess of Carbohydrates) into fat that is stored and increases our weight.
    • The glucose or its stored form glycogen is promoted. As excess of glucose is spared from conversion to fat, this excess glucose is mediated by gluconeogenesis pathway to form glycogen.
    • Glycogen signals the brain satiety center that sufficient food has been taken. So glycogen production with this herb further suppresses appetite.
    • Another of its action is on Central Nervous system. It raises the levels of Serotonin like brain neurotransmitters that has role in regulation of appetite.
    • This herb promotes thermogenesis process i.e. body's production of heat. This burns more calories and excess of stored fat.
    • The basic effects of Garcinia cambogia are to inhibit the enzymes in the body that turn excess carbohydrates into fat. By inhibiting this enzyme, the supplement then results in burning the extra carbohydrates with the added benefits of appetite suppression, decreased body fat and energy boosting.
 
Side Effects
There are no known adverse side effects in healthy adults taking Garcinia cambogia. People with Alzheimer's or other forms of dementia disease, pregnant and lactating women, children and people diagnosed with diabetes mellitus should avoid taking Garcinia cambogia.